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Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitati*** of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every ***ect of modern medicine, from infectious diseases to the***utics. However, it is unclea***hether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.

1 Genes and their expression 

? Dirk-Jan Kleinjan 

2 Epigenetic modification of chromatin 

? Donncha Dunican, Sari Pennings and Richard Meehan 

3 Population genetics and disease 

? Donald F. Conrad and Jonathan K. Pritchard 

4 Mapping common disease genes 

? Naomi R. Wray and Peter M. Visscher 

5 Population diversity, genomes and disease 

? Gianpiero L. Cavalleri and David B. Goldstein 

6 Study design in mapping complex disease traits 

? Harry Campbell and Igor Rudan 

7 Diseases of protein misfolding 

? Christopher M. Dobson 

8 Aging and disease 

? Thomas T. Perls 

9 The MHC paradigm: genetic variation and complex

disease 

? Adrian P. Kelly and John Trowsdale 

10?Less*** from single gene disorders 

? Nicholas D. Hastie 

11?Environment and disease 

? A.?J. McMichael and K.?B.?G. Dear 

12?Contemporary ethico-legal issues in genetics 

? Renate Gertz, Shawn Harmon and Geoffrey Pradella 

Section 2: Common Medical Disorders

13?Developmental disorders 

? Stephen P. Robertson and Andrew O.?M. Wilkie 

14?Genes, environment and cancer 

? D. Timothy Bishop 

15?The polygenic basis of breast cancer 

? Paul D.?P. Pharoah and Bruce A.?J. Ponder 

16?TP53: A master gene in normal and tumor suppression 

? Pierre Hainaut 

17?Genetics of colorectal cancer 

? Susan M. Farrington and Malcolm G. Dunlop 

18?Genetics of autoimmune disease 

? John I. Bell and Lars Fugger 

19?Susceptibility to infectious diseases 

? Andrew J. Walley and Adrian V.?S. Hill 

20?Inflammatory bowel diseases 

? Jean-Pierre Hugot 

21?Genetic anemias 

? W.?G. Wood and D.?R. Higgs 

22?Genetics of chronic disease: obesity 

? I. Sadaf Farooqi and Stephen O'Rahilly 

23?Type 2 diabetes mellitus 

? Mark I. McCarthy 

24?Genetics of coronary heart disease 

? Rossi Naoumova, Stuart A. Cook, Paul Cook and Timothy J.

Aitman 

25?Genetics of hypertension 

? B. Keavney and M. Lathrop 

26?Obstructive pulmonary disease 

? Bipen D. Patel and David A. Lomas

27?Skeletal disorders 

? Robert A. Colbert 

28?The genetics of common skin diseases 

? Jonathan Rees 

29?Molecular genetics of Alzheimer's disease and other ***-***et

dementias 

? P.?H. St Ge***e-Hyslop 

30?Major psychiatric disorders in *** life 

? Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter

McGuffin 

31?Speech and language disorders 

? Gabrielle Barnby and Anthony J. Monaco 

32?Common forms of visual handicap 

? Alan Wright 

33?Genetic and environmental influences on hearing

impairment 

? Karen P. Steel 

34?Pharmacogenomics: clinical applicati*** 

? Gillian Smith, Mark Chamberlain and C. Roland Wolf 

Index

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编辑推荐

　　Genes and Common Diseases presents an up-to-date view of the

role of genetics in modern medicine, reflecting the strengths and

limitati*** of a genetic perspective. The current shift in emphasis

from the study of rare single gene disorders to common diseases

brings genetics into every ***ect of modern medicine, from

infectious diseases to the***utics. However, it is unclea***hether

this increasingly genetic focus will prove useful in the face of

major environmental influences in many common diseases. The book

takes a hard and self-critical look at what can and cannot be

achieved using a genetic approach and what is known about genetic

and environmental mechanisms in a variety of common diseases. It

seeks to clarify the goals of human genetic research by providing

state-of-the art insights into known molecular mechanisms

underlying common disease processes while at the same time

providing a realistic overview of the expected genetic and

physiological complexity.

　　? Written by leading experts in genetics at a level that the

practising clinician can understand ? Introductory secti*** explain

the basics of genetics and molecular medicine, setting the scene

for the disease chapters in the following section ? Wide range of

clinical disorders covered and clear illustrati*** which help

explain complex genetic concepts

书籍介绍

Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitati*** of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every ***ect of modern medicine, from infectious diseases to the***utics. However, it is unclea***hether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.